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Nine Powerful Supplements to Reverse Heart Disease
Ronald Grisanti D.C., D.A.B.C.O., M.S.

Despite the “progress” of medical science over the last two decades, 50% of all Americans still die of cardiovascular disease. That statistic has remained unchanged for a long, long time. Think about that.

Half of my subscribers are going to die of heart attacks and strokes; half your family members are going to die of heart attacks or strokes; you, if you can reduce yourself to a statistic for a moment, stand a 50% chance of dying of a heart attack or a stroke.

In other words, we are all more likely to die of a heart attack or a stroke than of all other causes of death put together.

Medical science has yielded virtually nothing in the way of progress in this area, simply because it totally fails to address the issue of cause. All the many causative factors in cardiovascular disease can be reduced to a few simple categories:

  • oxidative damage to the heart
  • oxidative damage to the vascular system
  • oxidative metabolic insufficiency of the myocardium
  • oxidative metabolic inefficiency throughout the body leading to the build-up of easily oxidized lipid and sugar-protein complexes.

    There are no pharmaceuticals that can correct these causative factors, only that can minimize the effects.

    The good news for us is that there are ways to correct the causes of cardiovascular disease nutritionally.

    As a powerful reminder remember the truth about cholesterol.


    It is the other blood fat, triglycerides, which is an independent risk factor. In fact, it is one of the top three independent risk factors for cardiovascular disease.

    And nothing will lower serum triglycerides more effectively than the information in this report.

    Another risk factors for cardiovascular disease is homocysteine. It is the number one risk factor for cardiovascular disease, and there is only one way to lower it and that will soon be discussed.

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    The Four Dietary Rules To Beat Heart Disease

    A. Eat three meals daily, each of which includes a serving of meat, fish, poultry, eggs or cheese. (You MUST eat breakfast)
    B. Limited intake of sugar, including fruit.
    C. Strictly avoid juice and other sweetened beverages.
    D. Strictly avoid polyunsaturated oils (salad dressing, mayonnaise, margarine, foods containing vegetable oils or cooked in vegetable oils).

    If you follow these four rules,


    Fail to secure this degree of dietary compliance and you will be faced with an endless amount of frustration in your battle against heart disease. No supplement or pharmaceutical agent will achieve the kind of results adhering to the four fundamental dietary steps listed above.

    Write the list of four rules on a piece of paper and tape it to your refrigerator.

    Making allowances for holiday treats and other special occasions is no real problem. As long as the day-to-day eating plan follows these four rules, you are all set.

    Butter, olive oil, and coconut oil , are excellent concentrated fats that can be substituted for all the toxic catabolic vegetable oils. Eating adequate protein and good fat will suppress the abnormal cravings for sweets that most people experience between meals.

    Deleting the sweetened beverages will create the opportunity to even somewhat routinely indulge in a small serving of dessert (after a meal containing adequate protein) without rocking the boat too severely.

    Truly, there is a lot of freedom and flexibility here, such that you can thoroughly enjoy a scrumptious diet without indulging in damaging dietary practices.

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  • Carnosine, which strengthens and protects the heart and improves circulation.
  • Betaine, which lowers homocysteine, the number one risk factor for heart attacks and strokes.
  • Carnitine, which strengthens the heart muscle, while lowering both elevated cholesterol and triglycerides.
  • Coenzyme Q-10, which energizes and protects the heart, while protecting against atherosclerosis.
  • Palm tocotrienols, which clear serum lipids and protect the vascular system.
  • Gamma tocopherol, which protects and strengthens the heart and preserves the integrity of the vascular system.
  • Glucosamine, which maintains the structural integrity of arterial basement membranes.
  • Chondroitin Sulfate, which reverses atherosclerosis, protects against thrombus formation, strengthens the heart, and lowers cholesterol and triglycerides.

  • Alpha Lipoic Acid, which prevents atherosclerosis, and particularly lowers triglycerides.

  • Carnosine not only has anti-ischemic effects in the brain, but in the heart as well.
  • Carnosine has been shown to increase the strength of heart contractility by enhancing calcium response in heart cells.
  • Carnosine injections have been shown to be effective emergency treatment for ischemic crises
    start quoteIn the group of rats treated with carnosine, mortality after ischemic attack was decreased (from 55% to 17%) and most of the learning parameters were kept at the pre-ischemic level. end quote
    --Tohoku J Exp Med. 2000

    In the group of rats treated with carnosine, mortality after ischemic attack was decreased (from 55% to 17%) and most of the learning parameters were kept at the pre-ischemic level.

    In humans, carnosine levels decline with age. Muscle carnosine concentration decreases 63% from age 10 to age 70.

    Betaine facilitates the conversion of cholesterol into billiary acids in the liver for excretion through the gall bladder.

    The two obvious benefits are improved gall bladder function and a lowering of elevated serum cholesterol levels.

    The benefits of betaine extend to the cardiovascular system. It has been shown that betaine will actually decrease the incidence of thrombo embolisms. Add this to its cholesterol-lowering effect, and you will see that it is invaluable in the protection against cardiovascular disease.

    But wait – there is more.

    We have saved the best news on betaine for last.

    Research has shown that betaine (when combined with just very small amounts of vitamin B6 and folic acid will lower elevated homocysteine levels.

    Nothing else comes close to this powerful combination in lowering homocysteine.


    Carnitine has significant beneficial effects on myocardial energy production.

    Carnitine because is one of the most effective ways to lower elevated triglycerides (one of the few primary risk factors for heart attacks and strokes).

    Just what does carnitine do?

    Most fundamentally, carnitine transfers long-chained fatty acids into the mitochondria of cells.

    What are the benefits?

    Just consider this long list of biological effects attributed to carnitine in the scientific literature:

  • Carnitine appears to improve insulin resistance. It decreases the spike in glucose concentration after glucose administration, and decreases the associated insulin secretion.
  • Carnitine was shown to be beneficial in reducing chronic fatigue.
    Regarding its roll as a protector against cardiovascular disease, it has been shown that carnitine:

  • protects myocardial infarct patients against cardiac necrosis.
  • improves fat metabolism in the heart (as well as other organs)
  • decreases lipid peroxides in the heart.
  • improves heart muscle exercise tolerance.
  • decreases angina pain
  • is a vasodilator of coronary blood vessels, and lowers blood pressure.
  • decreases the elevated LDH levels in myocardial infarct patients.
  • decreases left ventricle enlargement.
  • decreases the incidence of arrythmias, including the occurrence of ventricular fibrillation in the early stages of ischemia.
  • decreases peripheral vascular disease.
  • decreases congestive heart failure.
  • has a dramatic impact on decreasing triglycerides. It decreases elevated cholesterol as well, but has a far greater effect on triglycerides. Carnitine also increases high density lipoproteins.
  • The corollary to the preceding statement is that studies have shown that a deficiency of carnitine is a causative factor in increasing triglycerides, both in the liver and in the serum.
    Are you beginning to appreciate the power you have to stop the progression of CVD, and in fact, to reverse it in many cases?

    Do not delay.


    CO-ENZYME Q-10
    Let us take a quick look now at the co-enzyme Q-10 that plays an important role your battle against heart disease.

    Co-Q10 is a powerful anti-oxidant that participates in several of the anti-oxidant systems. There are not too many nutrients that are more ubiquitous, and have more functions than Co-Q10.

    Not only is it a powerful anti-oxidant, it is essential to cellular energy production.


    There is one crucial consideration with respect to Co-Q10.

    Co-Q10 supplements are available in both dry powder and fat soluble form. Guess which one is more biologically active?

    Guess which one appears in 90+% of all nutrition supplements that contain Co-Q10?

    Consider these facts.

    In a recent clinical study, five hours after taking a 30 milligram dose of fat soluble Co-Q10, blood levels of Co-Q10 had increased by 237%. Meanwhile, five hours after a 30 milligram dose of the dry Co-Q10, the blood level increase was 112%. In other words, the fat soluble form was absorbed more than twice as well as the dry form.

    Another study looked at the effect of Co-Q10 supplementation in either dry or oil soluble form over a period of 30 days. After 30 days the fat soluble Co-Q10 group had increased their basal blood levels by 265%, while the dry formulation group only showed an increase of 180%.

    In addition, 83% of the subjects in the fat soluble Co-Q10 group experienced an increase in energy, compared to only 58% of those in the dry formulation group. Clearly, if you want the maximum benefit from Co-Q10 you want to use the oil soluble form as much as possible.

    start quoteDouble-blind placebo-controlled trials have definitely confirmed that coenzyme Q10 has a place as adjunctive treatment in heart failure with beneficial effects on the clinical outcome, the patients' physical activity, and their quality of life.end quote
    --Department of Cardiology and Internal Medicine, State University Hospital, Copenhagen.

    Double-blind placebo-controlled trials have definitely confirmed that coenzyme Q10 has a place as adjunctive treatment in heart failure with beneficial effects on the clinical outcome, the patients' physical activity, and their quality of life.

    Because of its specific beneficial impact on the cardiovascular system, there are two major problems with this allopathic approach to Co-Q10 use that assured its failure, and short-lived popularity.

    First, everyone was missing the point that Co-Q10 is far more effective when paired with other nutrients that have a synergistic affect. (the combination of the nine supplements listed in this report)

    The second, and the biggest shortcoming in people’s use of Co-Q10 as a single nutrient, was that they didn’t begin to use anything approaching a therapeutic dose.

    All the marvelous research on the effects of Co-Q10 on heart disease and other serious diseases used a therapeutic dose in the range of 90-120 milligrams.

    Yet, the typical Co-Q10 product available either in the health food store or from professionals such as yourself contained a paltry 10-30 milligrams, and was very expensive at that.

    So – what has been happening over so many years is that people go to their health food stores or their nutritionists and buy Co-Q10 in the therapeutically insignificant dose, spend a fortune on taking it for a few months, see no subjective or objective evidence of change in their health, and give up on it.

    They had gold in their hands and let it slip through their fingers.

    You have just learned that the fat soluble form of Co-Q10 is more than twice as biologically active as the dry form.

    Now consider this.

    Since most clinical studies with Co-Q10 use the dry powder form in determining the effective clinical dosage, you must realize that if you are getting fat soluble Co-Q10 you are actually getting a far higher dose than you may think.

    The Benefits of Co-Enzyme Q-10 Have Been Found To:

  • Prevent myocardial failure
  • Improve cardiac response to exercise
  • Lower high blood pressure
  • Reduce angina
  • Prevent arrythmias
  • Quench free radicals
  • Increase biochemical energy production
    Are You Certain You Are Taking The "CORRECT" Vitamin E?


    The Mixed Tocopherols and Tocotrienols

    The mixed tocopherols represent the complete vitamin E family – alpha, beta, gamma, and delta tocopherols.

    There is a lot of confusion among both the lay public and among doctors about vitamin E.

    Vitamin E is thought of, and properly so, as an antioxidant. Most people also think of Vitamin E primarily as alpha tocopherol, or, as one of the alpha tocopherol esters. As it turns out, what most people consider to be …


    Its antioxidant activity is positively dwarfed by the antioxidant activity of gamma tocopherol particularly, and the other tocopherols as well.

    But the thing you need to be most aware of regarding the tocotrienols is that they MUST be derived from palm.

    The few nutrition companies who are promoting a tocotrienol product are using a vastly inferior source. They are deriving their tocotrienols from rice bran.

    The reason this is a problem is because the tocotrienols from rice bran are almost totally lacking in the delta fraction of tocotrienols, which is by far the most biologically active antioxidant of the tocotrienol family.

    So, the situation is this – all the research done on the tremendous benefits of tocotrienols is done with tocotrienols derived from palm, which are very high in delta tocotrienol, while the pill peddlers are trying to sell you a tocotrienol product derived from rice bran, which is (obviously) cheaper in price, but gives you only a small portion of the benefits demonstrated in the scientific literature.

    start quoteThe benefits of palm oil to health include reduction in risk of arterial thrombosis and atherosclerosis, inhibition of endogenous cholesterol biosynthesis, platelet aggregation, and reduction in blood pressure.end quote
    --Department of Chemistry and Biochemistry, University of Uyo, Uyo, Akwa Ibom State, Nigeria.

    When you see Vitamin E on the label of a nutrition supplement, it is almost always one of the various forms of alpha tocopherol. It doesn’t matter whether the label says alpha tocopherol, alpha tocopheryl succinate, alpha tocopheryl acetate, vitamin E, natural vitamin E, or whatever, it is certain to be an alpha derivative.

    Now, when you see vitamin E on the label of foods and cosmetics, what kind of vitamin E do you have? Almost invariably you have mixed tocopherols. Why?

    While the label of the food or the cosmetic may be designed to imply that the vitamin E is there for your health benefit – they may have labeled it vitamin E, or even natural vitamin E – the truth is that that vitamin E is in the food or the cosmetic not for your benefit but to protect the product itself.

    In other words, to protect flavor and color, and to prevent the oxidative destruction of the critical components of the food or cosmetic, the manufacturer desperately needs a powerful antioxidant.

    Guess what’s in there? Mixed tocopherols.

    The point is that when you want a no holds barred antioxidant for a knock down drag out fight with oxidative stressors, you don’t fool around with the form of vitamin E they put in vitamin pills.

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    Gamma tocopherol has been measured in scientific research to be far more potent than alpha tocopherol in suppressing free radicals in living organisms.

    It is interesting to note that alpha tocopherol can actually displace gamma tocopherol in living tissues.

    So, now think about all the people that are taking 400, 800, or more international units of vitamin E each day in the belief that they are getting antioxidant protection, when actually they are destroying the most potent (and all too rare) antioxidant of all, gamma tocopherol.

    This is not to say that alpha tocopherol is bad. Quite the contrary. One form of alpha tocopherol, the ester alpha tocopheryl succinate is more effective in its role as an anti-thrombic agent than any of the other tocopherols, and it is more effective in boosting immune function.

    Interestingly, there is research showing that the combination of gamma tocopherol plus alpha tocopheryl succinate gives synergistic benefits in protection against cardiovascular disease, cancer, and many other diseases.

    Glucosamine is MORE than a supplement for arthritis

    The truth is, there have been dozens of scientific studies showing the benefits of glucosamine supplementation on cardiovascular health.

    What you are about to hear is the complete story on both glucosamine and chondroitin sulfate.

    You are about to read of the amazing diversity of beneficial effects to be obtained from these two nutrients.

    Once you realize the true powers they have to strengthen and protect yourself against heart disease with these two supplements, you will shake your head in disbelief that the natural food industry could relegate these two wonder workers to the status of mere arthritis remedies.

    First consider glucosamine. The nutrition establishment would have you thinking of this substance as nothing more than a raw material that forms a critical structural component of cartilage and other connective tissue.

    In other words, they give you a mental image of the glucosamine being swallowed, digested, circulated through the body to damaged or degenerating joint structures, then being deposited there as a purely structural component.

    That is an accurate picture of what happens, but only a partial picture. You see, glucosamine has functional roles that dwarf its structural role in importance. We are indebted to Rivici for doing much of the critical early research on glucosamine.

    Rivici's research revealed that glucosamine does not just strengthen connective tissue in a structural sense, but strengthens by protecting connective tissues against inflammation and maintains the structural integrity of arterial basement membranes.


    Far more important than its role in the connective tissue of joints is the power of chondroitin sulfate to maintain the functional integrity of the cardiovascular system.

    Just a few of the many benefits chondroitin sulfate confers on the cardiovascular system include:

  • CS helps maintain arterial elasticity. (Remember, arteries are largely connective tissue.)
  • CS retards the arteriosclerotic and aging processes within the arterial wall.
  • CS also possesses lipid clearing activity. It lowers cholesterol and triglycerides, and it normalizes the ratio between HDL, LDL, and VLDL. Most importantly, CS clears lipids not just in the serum but from within the cells as well.
  • CS supplementation has also been shown to significantly reduce angina in patients with cardiovascular disease.
  • CS has been found to protect against thrombus formation.
  • The most striking statistic regarding CS supplementation shows that in cardiovascular disease patients treated with CS, the likelihood of having a myocardial infarct, suffering coronary insufficiency or myocardial ischemia, or developing congestive heart failure, is only 1/6 of that reported for control patients who receive no CS supplementation.


    The institute for Arteriosclerosis Research reports experimental studies showing that CS not only prevents, it actually accelerates regression and healing of coronary and aortic atherosclerosis.

  • CS not only clears lipids at the cellular level, but also stimulates cellular metabolism, increases turnover of fatty acids at the cellular level, and increases RNA and DNA synthesis in tissue cultures.


    I am about to give you so much information about Alpha Lipoic Acid that your head will spin. Perhaps it is more information than you think you want – but I strongly suggest that you read every word of what follows. I am going to give you literally dozens of beneficial metabolic effects from lipoic acid, any one of which is in itself enough reason to supplement with lipoic acid.

    Alpha lipoic acid is a SUPER POWER antioxidant.

  • In its antioxidant role, lipoic acid has been shown to decrease diabetic neuropathy.
  • Lipoic acid increases T-Cell function in cancer patients.

  • Lipoic acid particularly decreases elevated systolic blood pressure, decreases excess cellular calcium, decreases elevated serum glucose and elevated serum insulin.
  • Lipoic acid also decreases adverse renal vascular changes associated with hypertension.
  • One interesting study compared the antioxidant effects of lipoic acid with those of alpha tocopherol (Vitamin E.)

    The results?

  • Lipoic acid effectively decreases LDL cholesterol.
  • One study showed that lipoic acid combined with selenium decreased Hepatitis C, decreased cirrhosis, decreased portal hypertension.
  • Lipoic acid increases energy availability to the brain and to muscles during exercise.
  • Lipoic acid increases intra cellular co-enzyme Q-10, and regenerates both vitamin C and vitamin E intracellularly.
  • Lipoic acid has been shown to improve cardiac autonomic neuropathy, which is diagnosed by reduced heart rate variability at rest.
  • Lipoic acid has been shown to decrease cataracts.
  • Lipoic acid has been shown to decrease age related memory loss
  • Lipoic acid has been shown to improve cardiac autonomic neuropathy, which is diagnosed by reduced heart rate variability at rest.
  • Lipoic acid has been shown in clinical studies to decrease elevated triglycerides by as much as 45%. (Elevated triglycerides (and not elevated cholesterol) is one of the few true risk factors for heart attacks and strokes)
  • Lipoic acid has been shown to decrease the tendency to calcium oxalate kidney stones.
  • Lipoic acid given to patients with coronary artery disease and essential hypertension has been shown to have a favorable influence on the fatty acid content of the blood.
    You cannot top that with any other supplemental products available anywhere.

    Alpha lipoic acid is available as a nutrient in both water soluble and fat soluble forms. Both forms are truly amazing in their biological effect, yet there are certain aspects of the effects of alpha lipoic acid which derive primarily from the fat soluble form. Probably at least 90% of the alpha lipoic products available to you are in the water soluble form only.

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    Dr. Grisanti's Comments

    Due to seriousness of heart disease and the wealth of information you have just learned, I am recommending a product that will provide all of the recommended supplements in one. The name of the product is called Di-Phasic AM and PM.

    Although I do not commonly sell products, I have not found anything that comes close to this product. If you were to purchase each of the above products separately, it would unfortunately be cost inhibited.

    If you would like some information on this product, please contact me at and let me know that you are interested in learning more about this wonderful product.

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    Researched and Written on April 11, 2004